![]() ![]() Thus, we exposed sunscreen-treated sites to four times the minimal erythema dose of solar simulating radiation, whereas vehicle and control sites were exposed to one minimal erythema dose. We tested the hypothesis that sun protection factors would indicate the level of protection against DNA photodamage. Both formulations had sun protection factors of 4 when assessed with solar simulating radiation in volunteers of skin type I/II. One formulation contained the established ultraviolet B filter octyl methoxycinnamate, whereas the other contained terephthalylidene dicamphor sulfonic acid, a new ultraviolet A filter. We assessed the ability of two sunscreens, with different spectral profiles, to inhibit DNA photodamage in human epidermis in situ. Sunscreens prevent sunburn and may also prevent skin cancer by protecting from ultraviolet-induced DNA damage.
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